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Therapeutic effects of bacteriophage Cpl-1 lysin against Streptococcus pneumoniae endocarditis in rats
J M Entenza1, J M Loeffler, D Grandgirard
1Department of Fundamental Microbiology, Biology Building, University of Lausanne, CH-1015 Lausanne, Switzerland. Jose.Entenza@unil.ch
Abstract:
Cpl-1, a pneumococcal phage lytic enzyme, was tested in rats with experimental endocarditis due to Streptococcus pneumoniae WB4. High-dose regimen Cpl-1 eliminated pneumococci from blood within 30 min and decreased bacterial titers in vegetations (>4 log10 CFU/g) within 2 h. Rapid bacterial lysis induced by Cpl-1 treatment increased cytokine secretion noticeably.
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