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Related Experiment Videos

Deterministic multiplicative gain control with active dendrites.

W Hamish Mehaffey1, Brent Doiron, Leonard Maler

  • 1Hotchkiss Brain Institute, University of Calgary, Calgary, Alberta, T2N 4N1, Canada. whmehaff@ucalgary.ca

The Journal of Neuroscience : the Official Journal of the Society for Neuroscience
|October 28, 2005
PubMed
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Researchers found a noise-free method for neural gain control using depolarizing afterpotentials (DAP). This mechanism allows neurons to adjust firing rates multiplicatively, with dendritic inhibition enabling divisive scaling and somatic inhibition enabling subtractive scaling.

Area of Science:

  • Neuroscience
  • Computational Neuroscience
  • Cellular Neuroscience

Background:

  • Multiplicative gain control is essential for neural computations, enabling neurons to scale firing rates based on synaptic input.
  • Existing theories often rely on noisy inputs, which can impair signal processing.
  • A deterministic method for gain control is needed to overcome the limitations of noisy inputs.

Purpose of the Study:

  • To demonstrate a deterministic method for multiplicative gain control in neurons.
  • To investigate the role of depolarizing afterpotentials (DAP) in neural gain control.
  • To differentiate the computational roles of dendritic and somatic inhibition.

Main Methods:

  • Investigated the impact of depolarizing afterpotentials (DAP) on neuronal firing rate.

Related Experiment Videos

  • Simulated the effects of dendritic inhibition on DAP amplitude and gain control.
  • Analyzed the impact of somatic inhibition on neuronal output.

    • Main Results:

    • Depolarizing afterpotentials (DAP), generated by dendritic spike backpropagation, induce multiplicative gain control.
    • Dendritic inhibition reduces DAP amplitude, leading to divisive scaling of firing rate.
    • Somatic inhibition acts subtractively, allowing for distinct computations by spatially segregated inputs.

    Conclusions:

    • A deterministic mechanism for multiplicative gain control exists, mediated by DAP.
    • Dendritic inhibition provides divisive scaling, while somatic inhibition provides subtractive scaling, enabling distinct neuronal computations.
    • The ubiquity of these components suggests widespread potential for dendritic division of neuronal output across cell types.