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Coronary risk variables in young asymptomatic smokers
S B Sharma1, S Dwivedi, K M Prabhu
1Departments of Biochemistry ,University College of Medical Sciences, Delhi, India. drsbs@hotmail.com
The Indian Journal of Medical Research
|October 28, 2005
Summary
Young male smokers show higher risks of hypertension, dyslipidemia, and oxidative stress, increasing susceptibility to premature coronary artery disease. These findings highlight the detrimental cardiovascular effects of smoking in this demographic.
Area of Science:
- Cardiovascular Science
- Preventive Cardiology
- Biochemistry
Background:
- Smoking is a major contributor to premature atherosclerosis, especially in South Asian males.
- It impacts cardiac hemodynamics, lipid profiles, and causes oxidative damage.
- Limited data exists from our region regarding these effects.
Purpose of the Study:
- To investigate the effects of smoking on electrocardiogram (ECG), blood pressure, and lipid profiles.
- To assess apolipoprotein B levels and free radical activity in young, asymptomatic male smokers.
- To provide local data on smoking-related cardiovascular risks.
Main Methods:
- A comparative study involving 100 male subjects (50 smokers, 50 non-smokers) aged 30-40 years.
- Evaluation included smoking history, cardiovascular assessment, ECG, and lipid profile analysis.
- Measurement of serum malondialdehyde and superoxide dismutase levels.
Main Results:
- Smokers exhibited higher rates of hypertension (44% vs 10%) and dyslipidemia (92% vs 48%).
- Significantly elevated total cholesterol, LDL-cholesterol, triglycerides, and apolipoprotein B were observed in smokers.
- Smokers showed increased serum malondialdehyde and decreased superoxide dismutase, indicating heightened oxidative stress.
Conclusions:
- Young asymptomatic male smokers present with hypertension, dyslipidemia, and increased oxidative stress.
- These factors predispose them to premature coronary artery disease.
- Larger studies are recommended to confirm these findings.
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