Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Engineering T cells for cancer therapy.

W Mansoor1, D E Gilham, F C Thistlethwaite

  • 1Cancer Research UK, Department of Medical Oncology, University of Manchester, Paterson Institute for Cancer Research, Christie Hospital NHS Trust, Withington, Manchester, UK.

British Journal of Cancer
|October 28, 2005
PubMed
Summary

Adoptive T-cell therapy shows promise for cancer treatment, particularly in melanoma. Gene therapy offers a rapid way to generate tumor-reactive T cells, overcoming limitations of natural T-cell production for clinical trials.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Controversies in upper gastrointestinal cancers: adoptive cell therapies.

ESMO gastrointestinal oncology·2026
Same author

Pembrolizumab plus chemotherapy versus chemotherapy for advanced esophageal cancer: 5-year extended follow-up for the randomized phase III KEYNOTE-590 study.

ESMO open·2025
Same author

Best-Practice Biomarker Testing of Oesophago-Gastric Cancer in the UK: Expert Consensus Recommendations Developed Using a Modified Delphi.

Clinical oncology (Royal College of Radiologists (Great Britain))·2024
Same author

Social determinants of health inequalities in early phase clinical trials in Northern England.

British journal of cancer·2024
Same author

Phase II trial of domatinostat (4SC-202) in combination with avelumab in patients with previously treated advanced mismatch repair proficient oesophagogastric and colorectal adenocarcinoma: EMERGE.

ESMO open·2024
Same author

The UK National Oesophagogastric Multidisciplinary Team Meeting: An Initiative From the UK & Ireland Oesophagogastric Group.

Clinical oncology (Royal College of Radiologists (Great Britain))·2023

Area of Science:

  • Immunology
  • Oncology
  • Gene Therapy

Background:

  • The immune system, particularly T cells, plays a crucial role in controlling tumor development.
  • Tumors can evade T-cell surveillance, leading to their progression despite immune presence.
  • Adoptive T-cell therapy is being explored to enhance anti-tumor immunity.

Purpose of the Study:

  • To review current gene therapy approaches for adoptive T-cell cancer treatment.
  • To discuss the potential and limitations of T-cell-based cancer therapies.
  • To highlight advancements moving towards clinical trials.

Main Methods:

  • Isolation, expansion, and re-infusion of tumor-specific T cells from biopsies.
  • Utilizing retroviral gene transfer to equip T cells with antigen-specific receptors.

Related Experiment Videos

  • Generating large numbers of tumor-reactive T cells rapidly via gene modification.

    • Main Results:

    • Feasibility of isolating and expanding tumor-specific T cells demonstrated.
    • Significant clinical responses observed in melanoma patients treated with adoptive T cells.
    • Gene therapy enables efficient engineering of T cells for cancer treatment.

    Conclusions:

    • Adoptive T-cell therapy holds significant potential for cancer treatment.
    • Technical challenges in producing natural tumor-specific T cells currently limit application.
    • Gene therapy approaches offer a promising strategy to overcome these limitations and advance clinical applications.