Nonlinear association between CGG repeat number and age of menopause in FMR1 premutation carriers
Sarah Ennis1, Daniel Ward, Anna Murray
1Genetic Epidemiology & Bioinformatics Group, Human Genetics Division, University of Southampton, Southampton, UK.
European Journal of Human Genetics : EJHG
|October 28, 2005
Abstract:
FMR1 premutations are known to be associated with premature ovarian failure (POF), but the underlying mechanism is unknown. We present evidence for a nonlinear association between menopause age and premutation size suggesting that premutations in the mid-size range are at greatest risk for POF, while larger premutations are at lower risk.
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