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Related Experiment Videos

Interaction analysis between 5-HTTLPR and TNFA -238/-308 polymorphisms in schizophrenia.

C-U Pae1, A Serretti, P Artioli

  • 1Department of Psychiatry, College of Medicine, The Catholic University of Korea, Kangnam St. Mary's Hospital, Banpo-Dong, Seocho-Gu, Seoul, Korea.

Journal of Neural Transmission (Vienna, Austria : 1996)
|October 28, 2005
PubMed
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Genetic variations in the serotonin transporter gene (5-HTTLPR) and tumor necrosis factor-alpha gene (TNFA) did not significantly impact schizophrenia development or treatment response in Koreans. However, a marginal link was found between specific TNFA and 5-HTTLPR alleles and family history.

Area of Science:

  • Genetics
  • Psychiatry
  • Molecular Biology

Background:

  • Schizophrenia is a complex psychiatric disorder with potential genetic underpinnings.
  • Polymorphisms in the serotonin transporter gene (5-HTTLPR) and tumor necrosis factor-alpha gene (TNFA) have been implicated in various neurological and psychiatric conditions.
  • Investigating gene-gene interactions is crucial for understanding schizophrenia's etiology.

Purpose of the Study:

  • To examine the interaction between 5-HTTLPR and TNFA polymorphisms ( -238G/A and -308G/A) in schizophrenia susceptibility.
  • To assess the combined effect of these polymorphisms on schizophrenia symptomatology, family history, age of onset, and antipsychotic treatment response.
  • To explore gene-gene interactions in a Korean population.

Main Methods:

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  • Genomic DNA was analyzed using polymerase chain reaction (PCR) for genotyping.
  • 152 patients with schizophrenia and 152 healthy controls were recruited.
  • Statistical analyses were performed to evaluate associations and interaction effects.

    • Main Results:

    • No significant association was found between individual 5-HTTLPR or TNFA polymorphisms and schizophrenia.
    • A marginal association was observed between combined TNFA -238 A allele and 5-HTTLPR s allele carriers with a positive family history of schizophrenia (p = 0.023; p = 0.026).
    • The TNFA -308 AG genotype was linked to a higher change in PANSS total score (p = 0.028), and a significant interaction effect for TNFA -238 AG and -308 AA genotypes was noted for positive family history (p = 0.017).

    Conclusions:

    • The interaction between 5-HTTLPR and TNFA polymorphisms does not significantly contribute to schizophrenia susceptibility or clinical variables in the Korean population.
    • Interactions may play a role in family history, but not significantly in treatment response or psychopathology.
    • Further research is needed to elucidate the complex genetic factors in schizophrenia.