Blood pressure responses to feeding in infancy: spin-offs of serendipity
Michael M Myers1, Harry N Shair, Morris Cohen
1New York State Psychiatric Institute, Department of Developmental Psychobiology, Columbia University College of Physicians and Surgeons, New, New York, USA. mmm3@columbia.edu
Insights
Feeding infants nutrient intake significantly increases heart rate and blood pressure. This research explores factors shaping these acute cardiovascular responses in newborns, linking nutrient availability to physiological changes.
Area of Science:
- Cardiovascular physiology
- Infant development
- Nutritional science
Background:
- Maternal behavior in rats linked to adult blood pressure.
- Nutrient availability identified as a key regulator of cardiovascular function in newborn rats.
Purpose of the Study:
- To understand infant cardiovascular responses to feeding.
- To identify factors influencing these acute responses.
- To explore the link between nutrient intake and cardiovascular function.
Main Methods:
- Observational studies in rats and human infants.
- Analysis of cardiovascular responses (heart rate, blood pressure) following nutrient ingestion.
Main Results:
- Nutrient ingestion in newborn rats and human infants is associated with significant increases in heart rate.
- Nutrient ingestion is also linked to robust increases in blood pressure in these young subjects.
Conclusions:
- Nutrient availability and ingestion are critical regulators of acute cardiovascular responses in infants.
- Feeding plays a significant role in shaping infant cardiovascular function.
- Further research can explore the long-term implications of these findings.
Abstract:
This article summarizes results from a program of research that has focused on understanding the characteristics of, and factors that shape, acute cardiovascular responses to feeding in infants. The work developed from behavioral observations in rats suggesting a linkage between variations in maternal behavior and adult blood pressure. However, the hypothesis that specific types of interactions, in particular those associated with feeding, might alter cardiovascular function was greatly influenced by a serendipitous observation made by Myron Hofer several years earlier. Myron discovered that nutrient availability is a key regulator of cardiovascular function in newborn rats. Our spin-off studies established that, in newborn rats and human infants, ingestion of nutrient is associated with robust increases in heart rate and blood pressure.
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