Related Experiment Video

Updated: Aug 15, 2026

Isolation of Lung Retinoid-Containing Cells by Cell Sorting
07:47

Isolation of Lung Retinoid-Containing Cells by Cell Sorting

Published on: April 11, 2025

Restrictive lung disease and serum TGF-beta1 in thalassemia major children

Suchada Sritippayawan1, Piyachat Lekhanont, Chanthana Harnruthakorn

  • 1Division of Pulmonology and Critical Care Medicine, King Chulalongkorn Memorial Hospital, Department of Pediatrics, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand. suchadacu@hotmail.com

Asian Pacific Journal of Allergy and Immunology
|October 29, 2005
PubMed

Insights

Restrictive lung disease in thalassemia major is linked to longer transfusion duration and higher ferritin. Serum TGF-beta1 levels did not show a significant association with restrictive lung disease in these children.

Area of Science:

  • Pediatric Hematology
  • Pulmonary Medicine
  • Biochemistry

Background:

  • Thalassemia major (TM) is a severe inherited blood disorder requiring lifelong transfusions.
  • Pulmonary complications, including restrictive lung disease (RLD), can affect TM patients.
  • The role of serum transforming growth factor-beta 1 (TGF-beta1) in RLD development in TM is not well understood.

Purpose of the Study:

  • To investigate the relationship between restrictive lung disease (RLD) and serum transforming growth factor-beta 1 (TGF-beta1) levels in children with thalassemia major.
  • To identify factors associated with RLD in this patient population.

Main Methods:

  • A cross-sectional study involving 21 children with thalassemia major.
  • Evaluation of pulmonary function, serum ferritin, and serum TGF-beta1 levels.
  • Comparison of RLD patients with non-RLD patients.

Main Results:

  • 24% of TM children exhibited restrictive lung disease (RLD).
  • RLD patients had significantly longer transfusion durations and higher serum ferritin levels compared to non-RLD patients.
  • Serum TGF-beta1 levels were significantly lower in TM children than in normal children, but not significantly different between RLD and non-RLD TM patients.

Conclusions:

  • Restrictive lung disease in thalassemia major is associated with prolonged transfusion history and elevated serum ferritin.
  • Serum TGF-beta1 levels do not appear to be a significant factor in the development of RLD in children with thalassemia major.

More Related Videos

Protocol and Guidelines for Point-of-Care Lung Ultrasound in Diagnosing Neonatal Pulmonary Diseases Based on International Expert Consensus06:15

Protocol and Guidelines for Point-of-Care Lung Ultrasound in Diagnosing Neonatal Pulmonary Diseases Based on International Expert Consensus

Published on: March 6, 2019

Related Concept Videos

TGF - β Signaling Pathway01:16

TGF - β Signaling Pathway

The TGF-β signaling pathway regulates cell growth, differentiation, adhesion, motility, and development. TGF-β ligands that induce TGF-β signaling are synthesized in their latent form. Several proteases or cell surface receptors such as integrins act upon the latent form, releasing the active ligand. There are three types of mammalian TGF-βs: (TGF-β1, TGF-β2, and TGF-β3) that bind as homodimers or heterodimers to TGF-β receptors. The TGF-β receptors are of three kinds RI, RII, and RIII. The RI...
Breathing01:05

Breathing

The process of breathing, inhaling and exhaling, involves the coordinated movement of the chest wall, the lungs, and the muscles that move them. Two muscle groups with important roles in breathing are the diaphragm, located directly below the lungs, and the intercostal muscles, which lie between the ribs. When the diaphragm contracts, it moves downward, increasing the volume of the thoracic cavity and creating more room for the lungs to expand. When the intercostal muscles contract, the ribs...