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Hepatic follicular dendritic cell sarcoma without Epstein-Barr virus expression
Ulises Torres1, William G Hawkins, Cristina R Antonescu
1Department of Surgery, Memorial Sloan-Kettering Cancer Center, New York, NY 10021, USA.
Archives of Pathology & Laboratory Medicine
|October 29, 2005
Summary
This study presents the first reported case of hepatic follicular dendritic cell sarcoma lacking Epstein-Barr virus infection. The findings detail the clinical and pathological features of this rare liver tumor.
Area of Science:
- Oncology
- Pathology
Background:
- Follicular dendritic cell sarcoma (FDCS) is a rare neoplasm.
- Hepatic FDCS is exceptionally uncommon, with limited prior case reports.
Observation:
- An elderly male patient presented with an incidental liver mass, followed by weight loss and fever.
- Diagnostic evaluation revealed a spindle cell proliferation with lymphoplasmacytic infiltrate and CD21/CD35 positivity.
Findings:
- This report details the first case of hepatic follicular dendritic cell sarcoma without Epstein-Barr virus (EBV) association.
- Morphological and immunohistochemical features confirmed the diagnosis.
Implications:
- This case expands the understanding of hepatic FDCS, particularly EBV-negative variants.
- Summarizes clinical, pathological, and surgical management strategies for hepatic FDCS.