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Antidepressant treatments and human aggression.

Alyson J Bond1

  • 1Division of Psychological Medicine, National Addiction Centre, PO 48, Institute of Psychiatry, King's College London, De Crespigny Park, UK. a.bond@iop.kcl.ac.uk

European Journal of Pharmacology
|October 29, 2005
PubMed
Summary

Antidepressants targeting serotonin and noradrenaline may reduce aggression by improving impulse control and social motivation. Studies show these treatments decrease negative mood and increase positive social behaviors.

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Area of Science:

  • Neuroscience
  • Psychopharmacology
  • Behavioral Science

Background:

  • Aggressive behavior is linked to negative mood and poor impulse control.
  • Serotonin is crucial for impulse regulation; its deficiency correlates with impulsive aggression.
  • Noradrenaline plays a role in social motivation, suggesting its relevance in aggression within social contexts.

Purpose of the Study:

  • To review evidence on the efficacy of serotonergic and noradrenergic antidepressants in reducing aggressive behavior.
  • To explore the distinct and potentially complementary mechanisms of these antidepressants on aggression.

Main Methods:

  • Review of evidence from clinical studies, including trials in personality disorder patients.
  • Analysis of experimental studies in healthy volunteers.

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  • Synthesis of findings from diverse sources on antidepressant effects on aggression.

    • Main Results:

    • Antidepressant treatment is associated with reduced negative mood and anger attacks.
    • Positive changes in personality traits, including increased assertiveness and affiliative behavior, were observed.
    • Clinical studies indicate serotonergic antidepressants can reduce irritability and impulsive aggression.

    Conclusions:

    • Both serotonergic and noradrenergic antidepressants show potential for reducing aggression through different pathways.
    • Serotonergic agents may improve impulse control, while noradrenergic agents might enhance social motivation.
    • Further controlled trials and experimental studies are needed to solidify these findings.