Related Experiment Video

Updated: Aug 15, 2026

Cell-free Biochemical Fluorometric Enzymatic Assay for High-throughput Measurement of Lipid Peroxidation in High Density Lipoprotein
07:29

Cell-free Biochemical Fluorometric Enzymatic Assay for High-throughput Measurement of Lipid Peroxidation in High Density Lipoprotein

Published on: October 12, 2017

Fasting apoprotein B-48 level and coronary artery disease in a population without frank fasting hypertriglyceridemia

René Valero1, Anne-Marie Lorec, Franck Paganelli

  • 1Service de Nutrition-Maladies Métaboliques-Endocrinologie, AP-HM, Hôpital Ste Marguerite, Université de la Méditerranée, CHU Marseille, BP 29-13274 Marseille Cedex 09, France. rvalero@mail.ap-hm.fr

Metabolism: Clinical and Experimental
|October 29, 2005
PubMed

Insights

Fasting apoprotein B-48 levels do not predict coronary artery disease (CAD) risk in individuals with normal fasting lipid profiles. This marker, associated with postprandial lipemia, showed no correlation with CAD presence or severity in the study population.

Area of Science:

  • Cardiovascular Disease Research
  • Lipid Metabolism Studies
  • Biomarker Discovery

Background:

  • Coronary artery disease (CAD) risk assessment often relies on fasting lipid profiles.
  • Postprandial lipemia is implicated in CAD pathogenesis but is challenging to assess routinely.
  • Apolipoprotein B-48 (ApoB-48) is a key component of chylomicrons and linked to postprandial lipemia.

Purpose of the Study:

  • To investigate if fasting apolipoprotein B-48 (ApoB-48) levels can serve as a surrogate marker for postprandial lipemia.
  • To evaluate the association between fasting ApoB-48 and the presence and severity of coronary artery disease (CAD).
  • To assess ApoB-48 as a predictor of CAD risk in individuals without overt fasting lipid abnormalities.

Main Methods:

  • A cohort of 123 patients undergoing coronary angiography, excluding those on lipid-lowering drugs or with hypertriglyceridemia, were studied.
  • Coronary artery disease (CAD) was defined by >50% vessel lumen narrowing; severity was graded by the number of affected arteries.
  • Fasting apolipoprotein B-48 (ApoB-48) levels were quantified using a competitive enzyme-linked immunosorbent assay (ELISA).

Main Results:

  • No significant difference in fasting apolipoprotein B-48 (ApoB-48) levels was observed between patients with and without coronary artery disease (CAD).
  • Fasting ApoB-48 levels did not correlate with the presence or severity of CAD, nor with age, sex, BMI, or standard fasting lipids.
  • ApoB-48 showed a correlation only with fasting triglyceride levels among metabolic syndrome features.

Conclusions:

  • Fasting apolipoprotein B-48 (ApoB-48) does not appear to be a reliable surrogate marker for postprandial lipemia in predicting coronary artery disease (CAD) risk.
  • In populations with normal fasting lipid profiles, fasting ApoB-48 levels do not predict CAD presence or severity.
  • Further research may be needed to identify effective biomarkers for postprandial lipemia and CAD risk assessment.

More Related Videos

Isolation and Analysis of Plasma Lipoproteins by Ultracentrifugation06:47

Isolation and Analysis of Plasma Lipoproteins by Ultracentrifugation

Published on: January 28, 2021

Network Pharmacology Prediction and Metabolomics Validation of the Mechanism of Fructus Phyllanthi against Hyperlipidemia11:06

Network Pharmacology Prediction and Metabolomics Validation of the Mechanism of Fructus Phyllanthi against Hyperlipidemia

Published on: April 7, 2023

Related Concept Videos

Lipid-Lowering Drugs: Statins and Miscellaneous Agents01:20

Lipid-Lowering Drugs: Statins and Miscellaneous Agents

Hyperlipidemia, a medical condition often referred to as high cholesterol, is characterized by abnormally elevated levels of lipids in the bloodstream. When present in excess, these lipids, specifically cholesterol and triglycerides, can lead to serious health complications, often involving cardiovascular diseases. Illnesses like atherosclerosis, heart attacks, and pancreatitis have all been linked to untreated hyperlipidemia. This means controlling and regulating cholesterol and triglyceride...
Cholesterol: Significance and Regulation01:29

Cholesterol: Significance and Regulation

Although not a source of energy, cholesterol plays a significant role as a foundational structure for bile salts, steroid hormones, and vitamin D, as well as being a crucial component of plasma membranes. Approximately 15% of blood cholesterol is derived from our diet, with the remainder synthesized from acetyl CoA by the liver and intestines. Cholesterol is eliminated from the body through its conversion into bile salts, which are eventually discarded in the feces.
Considering cholesterol and...
Blood Studies for Cardiovascular System II: CRP, Hcy, and Cardiac Natriuretic Peptide Markers01:19

Blood Studies for Cardiovascular System II: CRP, Hcy, and Cardiac Natriuretic Peptide Markers

Cardiac biomarkers are critical in diagnosing, prognosing, and managing cardiovascular diseases. Routine measurement of specific biomarkers such as B-type natriuretic peptide (BNP), C-reactive protein (CRP), and homocysteine (Hcy) is common practice in clinical settings to evaluate heart function and predict cardiovascular events.
These markers indicate stress or strain on the heart muscle:
Natriuretic Peptides (BNP)
Cardiac myocytes produce these hormones in response to ventricular stretching...
Blood Studies for Cardiovascular System III: Serum Lipid Profile01:25

Blood Studies for Cardiovascular System III: Serum Lipid Profile

Understanding serum lipids is crucial for maintaining cardiovascular health and preventing heart disease and stroke.
Serum lipids are fats and fatty substances in the blood and are crucial for various bodily functions, including energy storage, cellular structure, and hormone production. Serum lipids consist of cholesterol, triglycerides, and phospholipids.
Cholesterol is a soft, fat-like substance found in all body cells. It is crucial for producing hormones, vitamin D, and substances that aid...
Coronary Artery Disease I: Introduction01:30

Coronary Artery Disease I: Introduction

Coronary Artery Disease (CAD): An Overview with Scientific InsightsCoronary Artery Disease (CAD), often referred to as C-A-D, is a prevalent blood vessel disorder classified under the broader category of atherosclerosis. Atherosclerosis is a pathological process characterized by the hardening and narrowing of arteries due to the accumulation of atherosclerotic plaques. These plaques are composed of cholesterol, fatty substances, inflammatory cells, calcium, and fibrin, reducing blood flow to...
Hyperglycemia01:29

Hyperglycemia

Hyperglycemia is an abnormally high blood glucose level. It is diagnosed by fasting glucose ≥126 mg/dL, 2-hour oral glucose tolerance test (or OGTT) ≥200 mg/dL, random glucose ≥200 mg/dL with symptoms, or HbA1c ≥6.5%. However, HbA1c results may be unreliable in certain conditions, such as anemia or hemoglobinopathies, and the diagnosis should be confirmed unless classic symptoms are present. Postprandial hyperglycemia is typically considered significant when glucose levels exceed 180 mg/dL two...