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Pulse-Wave Velocity, Flow-Mediated Dilation, and Carotid Intima-Media Thickness to Assess Cardiovascular Risk in Population with Metabolic Syndrome
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Association between carotid artery intima-media thickness and cardiovascular risk factors in CKD

Emma Preston1, Mary R Ellis, Elena Kulinskaya

  • 1Renal Medicine, Faculty of Medicine, Imperial College London, Charing Cross Hospital, London, UK.

American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation
|October 29, 2005
PubMed

Insights

Common carotid artery intima-media thickness (CCA-IMT) is elevated in chronic kidney disease (CKD) patients. Arterial changes and dyslipidemia occur early in CKD progression.

Area of Science:

  • Nephrology
  • Cardiology
  • Vascular Biology

Background:

  • Common carotid artery intima-media thickness (CCA-IMT) is a marker for cardiovascular events and mortality.
  • CCA-IMT has not been extensively studied in patients with chronic kidney disease (CKD).

Purpose of the Study:

  • To evaluate CCA-IMT in patients with CKD.
  • To assess the relationship between CCA-IMT and cardiovascular risk factors in CKD patients.

Main Methods:

  • CCA-IMT was measured using high-resolution B-mode ultrasonography.
  • Glomerular filtration rate (GFR) was assessed via EDTA clearance.
  • Cardiovascular risk factors including lipid profiles, homocysteine, and smoking were evaluated.

Main Results:

  • CCA-IMT was significantly elevated in 114 CKD patients (0.59 cm) compared to controls (0.44 cm).
  • Elevated CCA-IMT correlated with increasing age and low-density lipoprotein levels.
  • CCA-IMT decreased with higher high-density lipoprotein levels and in white individuals.

Conclusions:

  • Arterial wall thickening occurs early in CKD progression.
  • Dyslipidemia may contribute to early arterial changes in CKD.
Abstract

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