The herpes simplex virus type 1 locus that encodes the latency-associated transcript enhances the frequency of
Clinton Jones1, Melissa Inman, Weiping Peng
1Department of Veterinary and Biomedical Sciences, Nebraska Center for Virology, University of Nebraska, Fair Street at East Campus Loop, Rm. 104, Lincoln 68583-0905, USA. cjones@unlnotes.unl.edu
Abstract:
Herpes simplex virus type 1 (HSV-1) is the leading cause of virus-induced encephalitis; however, the viral genes that regulate encephalitis have not been well characterized. In this study, we tested whether the LAT (latency-associated transcript) locus regulates the frequency of encephalitis in male or female mice. Male BALB/c mice are more susceptible to HSV-1-induced encephalitis than age-matched female BALB/c mice. Deletion of LAT coding sequences reduced the frequency of encephalitis. A recombinant virus containing the first 1.5 kb of the LAT coding sequence induces levels of encephalitis in male BALB/c mice similar to those induced by wild-type HSV-1.
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