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Colonic chicken-skin mucosa in children with polyps is not a preneoplastic lesion

Michael J Nowicki1, Phyllis R Bishop, Charu Subramony

  • 1Division of Pediatric Gastroenterology, University of Mississippi Medical Center, Jackson, Mississippi, USA.

Journal of Pediatric Gastroenterology and Nutrition
|October 29, 2005
PubMed

Insights

Chicken-skin mucosa (CSM) is not a preneoplastic lesion. Studies show CSM lacks markers for cell replication and malignant transformation, unlike adenomas and adenocarcinomas.

Area of Science:

  • Gastroenterology
  • Oncology
  • Pathology

Background:

  • Colonic polyps are common, with varying malignant potential.
  • Chicken-skin mucosa (CSM) was initially linked to preneoplastic lesions but later observed with benign juvenile polyps.
  • This raised questions about CSM's role in dysplasia.

Purpose of the Study:

  • To investigate whether chicken-skin mucosa (CSM) is a preneoplastic lesion.
  • To compare cell replication and malignant transformation markers in CSM versus other colonic tissues.

Main Methods:

  • Examined colonic mucosal biopsies using immunostaining for Ki-67 (cell replication) and p53 (malignant transformation).
  • Compared staining in CSM, normal colonic tissue, tubular adenomas, and adenocarcinomas.

Main Results:

  • Ki-67 staining was similar in CSM and normal tissue, but significantly higher in tubular adenomas and adenocarcinomas.
  • p53 staining was absent in CSM and normal tissue, but present in tubular adenomas and adenocarcinomas.

Conclusions:

  • CSM lacks histologic markers of increased cell replication and malignant transformation.
  • The findings suggest CSM is not preneoplastic and likely results from local mucosal damage near polyps of any type.

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