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Related Experiment Videos

Timed-urine collections for renal clearance studies.

Stanley Hellerstein1, Max Berenbom, Pat Erwin

  • 1Children's Mercy Hospital, 2401 Gillham Road, Kansas City, MO 64108, USA. shellers@cmh.edu

Pediatric Nephrology (Berlin, Germany)
|October 29, 2005
PubMed
Summary

Timed-urine collections for measuring renal clearance show good reproducibility. Variations in urine collection introduce a coefficient of variation (CV) of 12-14% in glomerular filtration rate (GFR) measurements, similar for children and adults.

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Area of Science:

  • Nephrology
  • Pediatric Nephrology
  • Clinical Chemistry

Background:

  • Accurate measurement of renal function is crucial in pediatric and adult patients.
  • Timed-urine collections are standard for renal clearance studies, but their reproducibility can impact results.
  • Glomerular filtration rate (GFR) is a key indicator of kidney function.

Purpose of the Study:

  • To assess the reproducibility of timed-urine collections in pediatric renal clearance studies.
  • To determine the impact of urine collection variability on glomerular filtration rate (GFR) measurements.

Main Methods:

  • Analysis of 222 cimetidine clearance studies (GFR-Cim) from 32 pediatric patients over 8 years.
  • Measurement of urinary creatinine excretion rates during supervised urine collection periods.

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  • Comparison of creatinine excretion rates within each child to evaluate urine collection reproducibility.

    • Main Results:

    • The coefficient of variation (CV) for creatinine excretion rate was approximately 10% in both children and adults.
    • The expected CV for GFR during repeated renal clearance studies using voided urine collections was 12% to 14% in both pediatric and adult subjects with stable GFR.

    Conclusions:

    • Timed-urine collections demonstrate acceptable reproducibility for renal clearance studies.
    • Variability in urine collection contributes a CV of 12-14% to GFR measurements, a consistent finding across pediatric and adult populations.
    • These findings support the reliability of timed-urine collections for assessing GFR in clinical settings.