Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

SCL gene in human tumors.

S Rockman1, C G Begley, G Kannourakis

  • 1Walter and Eliza Hall Institute of Medical Research, Victoria, Australia.

Leukemia
|July 1, 1992
PubMed
Summary

Rearrangements of the SCL gene are infrequent in myeloid leukemias and melanomas, despite its known role in T-cell acute lymphoblastic leukemia. This study found low SCL gene expression in various human tumors, indicating limited involvement in these cancers.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Identification and tentative removal of collagen glue in Palaeolithic worked bone objects: implications for ZooMS and radiocarbon dating.

Scientific reports·2023
Same author

Letter to the Editor: Comparison of Risk-Prediction Instruments in Frail Older Patients Diagnosed with COVID-19.

The Journal of frailty & aging·2022
Same author

An independent external validation of melanoma risk prediction models using the Australian Melanoma Family Study.

The British journal of dermatology·2020
Same author

Emerging Therapeutic Potential of Mesenchymal Stem/Stromal Cells in Preeclampsia.

Current hypertension reports·2020
Same author

Development and external validation study of a melanoma risk prediction model incorporating clinically assessed naevi and solar lentigines.

The British journal of dermatology·2019
Same author

Associations of pigmentary and naevus phenotype with melanoma risk in two populations with comparable ancestry but contrasting levels of ambient sun exposure.

Journal of the European Academy of Dermatology and Venereology : JEADV·2019

Area of Science:

  • Molecular Biology
  • Oncology
  • Genetics

Background:

  • The SCL gene, encoding a helix-loop-helix (HLH) transcription factor, is implicated in T-cell acute lymphoblastic leukemia (T-ALL).
  • Its role in other malignancies is less understood.

Purpose of the Study:

  • To investigate the frequency of SCL gene rearrangements and expression in a diverse range of primary human tumors.
  • To determine the involvement of SCL in myeloid leukemias and melanomas.

Main Methods:

  • Surveyed over 120 primary human tumors, including melanomas, myeloid and lymphoid leukemias, and other solid tumors.
  • Assessed SCL gene expression using a polymerase chain-reaction-based method.

Main Results:

  • No evidence of rearrangements involving the SCL gene was found in the surveyed tumors.

Related Experiment Videos

  • Low-level SCL gene expression was detected in these tumors.
  • SCL gene rearrangement/translocation is infrequent in myeloid leukemias and melanomas.

    • Conclusions:

    • SCL gene rearrangements are not a common mechanism in myeloid leukemias and melanomas.
    • The study provides evidence for the limited involvement of SCL gene alterations in these cancer types.