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Does hand osteoarthritis predict future hip or knee osteoarthritis?
S Dahaghin1, S M A Bierma-Zeinstra, M Reijman
1Dept. of General Practice, Erasmus Medical Center, University Medical Center Rotterdam, PO Box 1738, 3000 DR Rotterdam, The Netherlands. s_dahaghin@yahoo.com
Arthritis and Rheumatism
|October 29, 2005
Summary
Hand osteoarthritis increases the risk of developing hip and knee osteoarthritis later in life. This risk is further elevated by other osteoarthritis risk factors or a specific biomarker.
Area of Science:
- Rheumatology
- Orthopedics
- Epidemiology
Background:
- Osteoarthritis (OA) is a degenerative joint disease affecting millions worldwide.
- Hand OA is common, but its association with OA in other joints requires further investigation.
- Identifying early risk factors for OA progression is crucial for effective management.
Purpose of the Study:
- To determine if hand OA at baseline predicts future hip or knee OA.
- To assess if co-existing OA risk factors or a biomarker (CTX-II) amplify this risk.
Main Methods:
- Longitudinal study of 1,235 participants aged 55+ from the Rotterdam Study.
- Baseline hand, hip, and knee radiographs assessed for OA (Kellgren/Lawrence system).
- Follow-up radiographs at 6.6 years; CTX-II levels measured at baseline; logistic regression analysis.
Main Results:
- 12.1% developed hip/knee OA; 19.7% with hand OA vs. 10.0% without.
- Hand OA increased future hip OA risk (OR 3.0) and knee OA risk (OR 1.6).
- Combined hand OA with family history or overweight status further elevated risk; concurrent hand OA and high CTX-II showed OR 4.2.
Conclusions:
- Baseline hand OA is a significant predictor of future hip and knee OA.
- The risk of developing hip/knee OA is substantially higher when hand OA co-exists with other risk factors or elevated CTX-II levels.