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Evidence for common genetic control in pathways of inflammation for Crohn's disease and psoriatic arthritis

Pauline Ho1, Ian N Bruce, Alan Silman

  • 1University of Manchester, Stopford Building, Oxford Road, Manchester M13 9PT, UK. Pauline.Ho@manchester.ac.uk

Arthritis and Rheumatism
|October 29, 2005
PubMed

Insights

Psoriatic arthritis (PsA) shares genetic links with Crohn's disease, specifically involving the OCTN gene haplotype. This finding suggests common inflammatory pathways may underlie both conditions, impacting genetic research.

Area of Science:

  • Genetics and Immunology
  • Inflammatory Diseases
  • Molecular Biology

Background:

  • Growing evidence suggests shared genetic pathways in inflammatory diseases.
  • Previous research linked Crohn's disease gene CARD15 to psoriatic arthritis (PsA).
  • A Crohn's disease susceptibility locus involving OCTN genes (SLC22A4/SLC22A5) was recently identified.

Purpose of the Study:

  • To investigate the association of PsA with known Crohn's disease susceptibility genes.
  • To further elucidate shared genetic underpinnings between PsA and Crohn's disease.

Main Methods:

  • Genotyping of CARD15 and OCTN single-nucleotide polymorphisms (SNPs) in UK Caucasian PsA patients (n=472) and controls (n=594).
  • Analysis of a specific OCTN haplotype previously associated with Crohn's disease.
  • Comparison of allele and haplotype frequencies between patient and control groups.

Main Results:

  • No association was found between PsA and CARD15.
  • A significant association was detected between PsA and a functional SNP in SLC22A5 (rs2631367).
  • The Crohn's disease-associated OCTN haplotype was also significantly associated with PsA (P=0.001).

Conclusions:

  • The OCTN haplotype linked to Crohn's disease is also associated with PsA.
  • These findings support the hypothesis that PsA and Crohn's disease share common genetic control mechanisms in inflammatory pathways.
  • No association was observed in patients with psoriasis alone or undifferentiated inflammatory arthritis.
Abstract

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