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Related Experiment Videos

Cat-scratch disease-associated arthropathy.

Michael Giladi1, Eran Maman, Daphna Paran

  • 1Pridan Laboratory for Molecular Biology of Infectious Diseases, Ichilov Hospital, Tel-Aviv Sourasky Medical Center, 6 Weizman Street, Tel-Aviv 64239, Israel. mgiladi@zahav.net.il

Arthritis and Rheumatism
|October 29, 2005
PubMed
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Cat-scratch disease (CSD) can cause severe, disabling joint pain (arthropathy) in nearly 3% of patients, particularly young to middle-aged women. While most recover, some cases develop chronic joint issues lasting months to years.

Area of Science:

  • Infectious Diseases
  • Rheumatology
  • Epidemiology

Background:

  • Cat-scratch disease (CSD), caused by Bartonella henselae, is typically known for lymphadenopathy.
  • Articular manifestations of CSD are less understood but can significantly impact patient well-being.

Purpose of the Study:

  • To comprehensively characterize the articular manifestations of CSD.
  • To evaluate the long-term clinical outcomes of CSD-associated arthropathy.

Main Methods:

  • A surveillance study in Israel (1991-2002) identified CSD patients with arthropathy (arthritis/arthralgia).
  • Confirmed CSD diagnosis via serology and/or PCR for Bartonella henselae.
  • Patients with arthropathy were followed for symptom resolution or up to 12 months; controls without arthropathy were included.

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Main Results:

  • 2.9% of 841 CSD patients developed rheumatoid factor-negative arthropathy, often severe and disabling.
  • Risk factors included female sex, age over 20, and erythema nodosum.
  • Knee, wrist, ankle, and elbow joints were commonly affected; 42% had severe arthropathy impacting mobility.
  • While 79.2% recovered within weeks, 20.8% experienced chronic disease lasting months to years.

Conclusions:

  • CSD-associated arthropathy is an uncommon but potentially severe and disabling condition.
  • The syndrome predominantly affects young to middle-aged women.
  • A significant minority of patients may experience a chronic, persistent course of joint disease.