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Recombinant human superoxide dismutase can attenuate ischemic neuronal damage in gerbils
M Tagaya1, M Matsumoto, K Kitagawa
1First Department of Internal Medicine, Osaka University Medical School, Japan.
Life Sciences
|January 1, 1992
Abstract:
The effects of recombinant human superoxide dismutase (r-hSOD) on ischemic neuronal injury were examined. Cerebral ischemia was produced in Mongolian gerbils by occluding bilateral common carotid arteries for 5 min. Preischemic treatment with r-hSOD clearly reduced hippocampal neuronal damages while postischemic treatment did not. This result suggests that oxygen free radicals play an important role in selective vulnerability to ischemia and r-hSOD has a potential clinical usefulness against cerebral ischemia.