Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Probiotics under the regulatory microscope.

Anders Henriksson1, Thomas Borody, Robert Clancy

  • 1DSM Food Specialties Australia, Moorebank, NSW, Australia.

Expert Opinion on Drug Safety
|November 1, 2005
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Deep profiling of lupus nephritis kidneys reveals dynamic changes in myeloid cells associated with disease progression.

Annals of the rheumatic diseases·2026
Same author

Amplitude integrated electroencephalography for neonatal seizure detection: an alternative opinion to the 2025 Cochrane review.

Pediatric research·2026
Same author

Comparative Performance of LFA-REAL, SLEDAI, and BILAG for Detecting Clinically Meaningful Changes in Lupus Activity.

Arthritis care & research·2026
Same author

Blocking the neonatal Fc receptor as a novel approach to prevent cardiac neonatal lupus: a proof-of-concept study.

Annals of the rheumatic diseases·2025
Same author

Long read metagenomics-based precise tracking of bacterial strains and genomic changes after fecal microbiota transplantation.

bioRxiv : the preprint server for biology·2025
Same author

CAR T-cell therapy in SLE: A systematic review.

Seminars in arthritis and rheumatism·2025

This review explores the safety of probiotic bacteria, highlighting evolving regulations and potential risks for immune-deficient individuals. Further research is needed on antibiotic resistance transfer and non-gut applications of probiotics.

Area of Science:

  • Microbiology
  • Immunology
  • Pharmacology

Background:

  • Probiotic bacteria are increasingly used therapeutically beyond the food industry.
  • Current safety standards require enhancement as probiotic applications become more complex.
  • Probiotics are viewed as nonspecific promoters of mucosal immunity.

Purpose of the Study:

  • To review current knowledge on the safety of probiotic bacteria in humans.
  • To identify emerging challenges and areas needing further investigation in probiotic therapy.
  • To propose a framework for evaluating probiotic characteristics and clinical use.

Main Methods:

  • Comprehensive literature review of existing studies on probiotic safety.
  • Analysis of regulatory trends and evolving standards for probiotic products.

Related Experiment Videos

  • Examination of clinical data and potential risks associated with probiotic use.

    • Main Results:

    • Individuals with immune deficiencies may face increased risks with high-dose probiotic consumption.
    • Broader bacterial diversity and non-gut applications necessitate updated safety assessments.
    • Concerns exist regarding antibiotic resistance transfer and the use of non-selected fecal isolates.

    Conclusions:

    • Probiotic therapy is entering a new therapeutic arena, requiring stricter regulations and comprehensive safety evaluations.
    • Further research is crucial to clarify risks, particularly concerning antibiotic resistance and diverse applications.
    • A nuanced framework is needed to guide the safe and effective use of probiotics.