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Related Experiment Videos

Systemic sarcoidosis: the "leopard-man" sign.

Fouad Fayad1, Michèle Duet, Philippe Orcel

  • 1Rheumatology Federation, Viggo Petersen Center, Lariboisière Teaching Hospital, Paris (AP-HP), France.

Joint Bone Spine
|November 1, 2005
PubMed
Summary
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Systemic sarcoidosis can be diagnosed late. A unique "dappled-body sign" on Gallium-67 scintigraphy aided in diagnosing this condition in a patient with suspected tuberculosis.

Area of Science:

  • Rheumatology and Immunology
  • Nuclear Medicine
  • Dermatology

Background:

  • Systemic sarcoidosis is a multisystem inflammatory disease often presenting with delayed diagnosis.
  • Initial misdiagnosis as tuberculosis can occur, leading to ineffective treatments.
  • Characteristic scintigraphic patterns may aid in early and accurate diagnosis.

Observation:

  • The patient exhibited subcutaneous, cutaneous, muscular, mediastinal, and lachrymal gland involvement.
  • Gallium-67 scintigraphy revealed a distinctive diffuse dappled pattern across multiple organs and tissues.
  • Magnetic resonance imaging confirmed extensive muscular and subcutaneous disease.

Findings:

  • The scintigraphic findings were described as a "dappled-body sign" or "leopard-man sign."

Related Experiment Videos

  • The patient's presentation and imaging findings were consistent with systemic sarcoidosis.
  • Initial treatment for presumed tuberculosis was ineffective.

    • Implications:

    • The "dappled-body sign" may serve as a novel diagnostic indicator for systemic sarcoidosis.
    • Early recognition of this scintigraphic pattern can expedite diagnosis and treatment.
    • Effective management with prednisone was demonstrated, highlighting treatment responsiveness.