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Updated: Aug 15, 2026

Isolation of Physiologically Active Thylakoids and Their Use in Energy-Dependent Protein Transport Assays
Published on: September 28, 2018
Protein transport in Archaea: Sec and twin arginine translocation pathways
Mechthild Pohlschröder1, María Inés Giménez, Ken F Jarrell
1Biology Department, University of Pennsylvania, Philadelphia, PA 19104, USA. pohlschr@sas.upenn.edu
Abstract:
The transport of proteins into and across hydrophobic membranes is an essential cellular process. The majority of proteins that are translocated in an unfolded conformation traverse the membrane by way of the universally conserved Sec pathway, whereas the twin arginine translocation pathway is responsible for the transport of folded proteins across the membrane. Structural, biochemical and genetic analyses of these processes in Archaea have revealed unique archaeal features, and have also provided a better understanding of these pathways in organisms of all domains. Further study of these pathways in Archaea might elucidate fundamental principles involved in each type of transport and could help determine their relative costs and benefits as well as evolutionary adaptations in protein secretion strategies.
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