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Elevation of serum thioredoxin levels in patients with nonalcoholic steatohepatitis
Toshiaki Nakashima1, Yoshio Sumida, Masanori Furutani
1Department of Internal Medicine, Saiseikai Kyoto Hospital, Imazato-minamihirao, Nagaoka-kyo, Kyoto 617-0814, Japan.
Abstract:
Thioredoxin (TRX) is induced by many oxidative stresses. Serum TRX levels were significantly elevated in nonalcoholic steatohepatitis (NASH) patients, as compared to simple fatty liver (FL) patients or healthy controls. Serum TRX levels in NASH patients were significantly correlated with serum ferritin levels, but not with other variables. Removal of hepatic excess iron by phlebotomy significantly decreased the serum levels of TRX and ALT in NASH patient. Therefore, the pathogenesis of NASH may be associated with iron-related oxidative stress. The serum TRX level is a parameter for discriminating NASH from FL.