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Updated: Aug 15, 2026

A Restriction Enzyme Based Cloning Method to Assess the In vitro Replication Capacity of HIV-1 Subtype C Gag-MJ4 Chimeric Viruses
Published on: August 31, 2014
Preparing for phase II/III HIV vaccine trials in Africa
Eftyhia Vardas1, Stefano Buttò, Richard Glashoff
1Perinatal HIV Research Unit, University of the Witwatersrand, PO Box 114, Diepkloof 1864, Johannesburg, South Africa. vardase@mweb.co.za
Abstract:
Before performing phase II/III clinical trials in Africa, preliminary studies, including assessment and building up of clinical and laboratory infrastructures, estimates of human immunodeficiency virus incidence, investigation of the background immune response, and evaluation of the cross-clade immune response, need to be done. Plans and ongoing work in the context of the AIDS Vaccine Integrated Project and some preliminary data are presented.

