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Familial Alzheimer's mutation: mRNA secondary structure revisited
1Fishberg Research Center for Neurobiology, Mount Sinai School of Medicine, New York, NY 10029.
Neurobiology of Aging
|May 1, 1992
Abstract:
It has been suggested that the mutation at position 717 of the amyloid precursor protein (APP), found in several cases of familial Alzheimer's disease, affects the secondary structure of the corresponding messenger RNA and the rate of its translation (10). Phylogenetic analysis based on comparison with other mammalian APP sequences does not support this possibility.