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Isolated office hypertension: a 3-year follow-up study
Anna M Grandi1, Francesco Solbiati, Emanuela Laurita
1Department of Clinical Medicine, University of Insubria, Varese, Italy. amgrandi@libero.it
Blood Pressure
|November 1, 2005
Summary
Patients with isolated office hypertension have a high risk of developing sustained hypertension within 3 years. Early left ventricular diastolic changes predict this progression, highlighting the need for monitoring.
Area of Science:
- Cardiology
- Hypertension Research
- Clinical Medicine
Background:
- Isolated office hypertension (IOH) is defined by elevated clinic blood pressure (BP) with normal daytime ambulatory BP.
- The long-term cardiovascular implications and progression of IOH require further investigation.
Purpose of the Study:
- To assess the 3-year progression to sustained hypertension in patients with IOH.
- To identify predictors of hypertension development, focusing on left ventricular (LV) changes.
Main Methods:
- A 3-year longitudinal study involving 24-h ambulatory BP monitoring and echocardiography.
- Comparison of baseline and follow-up BP and LV parameters in normotensive and IOH groups.
Main Results:
- 72% of patients with baseline IOH developed sustained (ambulatory) hypertension over 3 years.
- Lower baseline LV diastolic parameters, LV hypertrophy, and preclinical diastolic dysfunction were associated with progression to sustained hypertension.
Conclusions:
- Patients with IOH exhibit a high rate of progression to sustained hypertension.
- Baseline LV hypertrophy and diastolic dysfunction are significant predictors of future sustained hypertension.
