Related Experiment Videos
Basic fibroblast growth factor (bFGF) acts centrally in the brain to inhibit gastric emptying in rats
T Okumura1, A Uehara, S Kitamori
1Department of Internal Medicine III, Asahikawa Medical College, Hokkaido, Japan.
Neuroscience Letters
|March 16, 1992
Abstract:
In the present study, we evaluated the central nervous system action of basic fibroblast growth factor (bFGF) on gastric emptying of a liquid meal in conscious rats using a Phenol red method. Intracisternal injection of bFGF dose-dependently inhibited gastric emptying, while intraperitoneal injection of bFGF at the same doses failed to alter gastric emptying. These results suggest for the first time that bFGF acts in the central nervous system to delay gastric emptying.