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Updated: Jan 19, 2026

Generation of Discriminative Human Monoclonal Antibodies from Rare Antigen-specific B Cells Circulating in Blood
Published on: February 6, 2018
Antibody engineering for the development of therapeutic antibodies
Sang Jick Kim1, Youngwoo Park, Hyo Jeong Hong
1Laboratory of Antibody Engineering, Korea Research Institute of Bioscience and Biotechnology, Daejeon 305-333, Korea.
Abstract:
Therapeutic antibodies represent one of the fastest growing areas of the pharmaceutical industry. There are currently 19 monoclonal antibodies in the market that have been approved by the FDA and over 150 in clinical developments. Driven by innovation and technological developments, therapeutic antibodies are the second largest biopharmaceutical product category after vaccines. Antibodies have been engineered by a variety of methods to suit a particular therapeutic use. This review describes the structural and functional characteristics of antibody and the antibody engineering for the generation and optimization of therapeutic antibodies.
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