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Updated: Aug 15, 2026
08:08
Quantitative Mass Spectrometric Profiling of Cancer-cell Proteomes Derived From Liquid and Solid Tumors
Published on: February 27, 2015
Cancer pharmacogenomics may require both qualitative and quantitative approaches
1Hematological Malignancies Program, Department of Pharmaceutical Sciences, St. Jude Children's Research Hospital, Memphis, Tennesee 38105, USA.
Cell Cycle (Georgetown, Tex.)
|November 1, 2005
Summary
Overcoming chemotherapy drug resistance is crucial for cancer treatment. Pharmacogenomics, studying genetic influences on drug response, offers a path to personalized cancer therapies and improved patient outcomes.
Area of Science:
- Oncology
- Pharmacogenomics
- Cancer Biology
Background:
- Chemotherapy resistance significantly contributes to cancer mortality.
- Anticancer drugs often have a narrow therapeutic index, balancing efficacy with toxicity.
- Advances in understanding cancer pathobiology and drug response have improved survival rates.
Purpose of the Study:
- To highlight the importance of overcoming chemotherapy drug resistance.
- To emphasize the role of pharmacogenomics in understanding drug efficacy and toxicity.
- To suggest the need for genomic analyses in cancer pharmacogenomics.
Main Methods:
- Review of current research on cancer chemotherapy and drug resistance.
- Exploration of advances in understanding cancer pathobiology and inter-individual drug response.
- Discussion of pharmacogenomics as a tool for elucidating genetic determinants of drug effects.
Main Results:
- Significant progress in event-free survival for some cancers, like childhood acute lymphoblastic leukemia (ALL).
- Identification of inter-individual differences in drug effects and treatment response.
- Emerging evidence suggests both qualitative and quantitative genomic analyses are vital for cancer pharmacogenomics.
Conclusions:
- Further knowledge in cancer biology and chemotherapy mechanisms will drive new drug development.
- Personalized medicine approaches, informed by pharmacogenomics, are key to effective cancer treatment.
- Genomic characterization is essential for optimizing cancer pharmacogenomics.
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