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Autoimmune pancreatitis with hepatic inflammatory pseudotumor
Atsushi Kanno1, Kennichi Satoh, Kenji Kimura
1Division of Gastroenterology, Tohoku University Graduate School of Medicine, Sendai, Japan. atsushih@cocoa.ocn.ne.jp
Pancreas
|November 1, 2005
Summary
This case report details a patient with autoimmune pancreatitis (AIP) and hepatic inflammatory pseudotumor (IP). The findings suggest a link between these conditions and IgG4-related systemic disease.
Area of Science:
- Gastroenterology and Hepatology
- Immunology
- Pathology
Background:
- Autoimmune pancreatitis (AIP) is a chronic inflammatory condition.
- Hepatic inflammatory pseudotumor (IP) is a benign liver lesion of unknown etiology.
- The patient presented with symptoms suggestive of cholangiocarcinoma and AIP.
Observation:
- The patient underwent liver lobectomy for suspected metastatic cancer.
- Histological examination revealed lymphoplasmacytic infiltration and obliterating phlebitis in the liver and pancreas.
- No evidence of neoplastic proliferation was found in the resected liver or pancreatic biopsy.
Findings:
- The lesions showed abundant IgG4-positive plasma cells.
- This case represents the first report of simultaneous hepatic IP and AIP.
- The findings support the hypothesis of IgG4-related systemic disease.
Implications:
- Simultaneous AIP and hepatic IP may indicate an underlying IgG4-related systemic disease.
- This case expands the spectrum of manifestations for IgG4-related disorders.
- Further research is needed to elucidate the pathogenesis and diagnostic criteria for IgG4-related systemic disease.