Related Experiment Video

Updated: Aug 11, 2026

A Magnetic Resonance Imaging Protocol for Stroke Onset Time Estimation in Permanent Cerebral Ischemia
09:59

A Magnetic Resonance Imaging Protocol for Stroke Onset Time Estimation in Permanent Cerebral Ischemia

Published on: September 16, 2017

C-reactive protein is an indicator for fatal outcomes in first-time stroke patients

Abdulkadir Koçer1, Cüneyt Canbulat, Eren Gözke

  • 1Department of Neurology, PTT Teaching Hospital, Istanbul, Turkey. abdulkadirkocer@yahoo.com

Medical Science Monitor : International Medical Journal of Experimental and Clinical Research
|November 1, 2005
PubMed

Insights

Elevated high-sensitivity C-reactive protein (hsCRP) levels are significantly higher in first-time ischemic stroke patients compared to controls. High hsCRP may indicate a fatal outcome within six months for these patients.

Area of Science:

  • Cardiology
  • Neurology
  • Inflammation Research

Background:

  • The link between high-sensitivity C-reactive protein (hsCRP) and ischemic cerebrovascular disease is not fully understood.
  • Inflammatory processes are suspected to play a role in stroke development.

Purpose of the Study:

  • To compare serum hsCRP levels in ischemic stroke patients versus a control group.
  • To investigate correlations between hsCRP levels and known risk factors for stroke.

Main Methods:

  • 47 ischemic stroke patients and 26 controls were enrolled, matched for age and sex.
  • Serum hsCRP levels were measured using a chemiluminescence assay 12-24 hours post-stroke.

Main Results:

  • Stroke patients exhibited significantly higher mean hsCRP levels (3.12 ± 4.4 mg/dL) than controls (0.39 ± 0.6 mg/dL).
  • Elevated hsCRP levels were observed in 83% of patients and 27% of controls.
  • hsCRP correlated with hypertension and predicted death within six months, but not other vascular risk factors besides cholesterol.

Conclusions:

  • Elevated serum hsCRP levels may serve as a prognostic marker for adverse outcomes in first-time ischemic stroke patients.
  • This finding highlights the potential role of inflammation in stroke severity and prognosis.
Abstract

More Related Videos

Evaluation of Coronary Flow Reserve After Myocardial Ischemia Reperfusion in Rats06:32

Evaluation of Coronary Flow Reserve After Myocardial Ischemia Reperfusion in Rats

Published on: June 28, 2019

A Fibrin-Enriched and tPA-Sensitive Photothrombotic Stroke Model09:42

A Fibrin-Enriched and tPA-Sensitive Photothrombotic Stroke Model

Published on: June 4, 2021

Related Concept Videos

Blood Studies for Cardiovascular System I: Cardiac Biomarkers01:20

Blood Studies for Cardiovascular System I: Cardiac Biomarkers

Cardiac biomarkers are enzymes, proteins, and hormones released into the blood when cardiac cells are injured. They are powerful tools for triaging.
The essential diagnostic tools for detecting myocardial necrosis and monitoring individuals suspected of having acute coronary syndrome (ACS) include:
Troponins
Troponins, particularly cardiac troponins I and T, are the most precise and sensitive markers of myocardial injury. They are detectable within 4-6 hours of myocardial injury and remain...
Blood Studies for Cardiovascular System II: CRP, Hcy, and Cardiac Natriuretic Peptide Markers01:19

Blood Studies for Cardiovascular System II: CRP, Hcy, and Cardiac Natriuretic Peptide Markers

Cardiac biomarkers are critical in diagnosing, prognosing, and managing cardiovascular diseases. Routine measurement of specific biomarkers such as B-type natriuretic peptide (BNP), C-reactive protein (CRP), and homocysteine (Hcy) is common practice in clinical settings to evaluate heart function and predict cardiovascular events.
These markers indicate stress or strain on the heart muscle:
Natriuretic Peptides (BNP)
Cardiac myocytes produce these hormones in response to ventricular stretching...
Rheumatic Heart Disease II: Clinical Manifestations and Diagnostic Studies01:22

Rheumatic Heart Disease II: Clinical Manifestations and Diagnostic Studies

The key clinical manifestations of Rheumatic heart disease (RHD) include several distinct cardiac symptoms.Carditis, a hallmark of acute rheumatic fever, involves inflammation of the heart's endocardium, myocardium, and pericardium. Chronic RHD often results from recurrent episodes of carditis. Its symptoms include the following:Murmurs are caused by valvular damage, especially to the mitral and aortic valves. Mitral stenosis or regurgitation is common, with characteristic heart murmurs...
Acute Coronary Syndrome I: Introduction01:30

Acute Coronary Syndrome I: Introduction

Acute Coronary Syndrome (ACS) encompasses a spectrum of heart conditions caused by sudden obstruction of coronary arteries, typically resulting from the rupture of an atherosclerotic plaque and subsequent thrombus (blood clot) formation. This obstruction can lead to partial or complete blockage of blood flow, causing varying degrees of myocardial ischemia or infarction.ACS includes the following clinical entities:Unstable Angina (UA)Non-ST-Elevation Myocardial Infarction (NSTEMI)ST-Elevation...
Acute Coronary Syndrome III: Diagnostic Studies01:30

Acute Coronary Syndrome III: Diagnostic Studies

Diagnosing acute coronary syndrome or ACS begins with a thorough patient history. Notable symptoms include central, crushing chest pain radiating to the left arm, neck, jaw, or back, along with shortness of breath, sweating (diaphoresis), nausea, vomiting, dizziness, and palpitations.It is crucial to note any history of cardiac illnesses and assess risk factors, including age, gender, smoking, hypertension, diabetes, hyperlipidemia, and a sedentary lifestyle.During physical examination, vital...
Ischemic Stroke ll: Pathophysiology01:15

Ischemic Stroke ll: Pathophysiology

An ischemic stroke occurs when a cerebral blood vessel becomes obstructed, most often by a thrombus or embolus, interrupting the delivery of oxygen and glucose to brain tissue. Because neurons rely on continuous aerobic metabolism, energy failure begins within minutes of reduced perfusion. The region receiving the least blood flow becomes the infarct core, an area of irreversible cellular death. Surrounding this core lies the penumbra, a zone of hypoperfused but still viable tissue that is...