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Updated: Aug 15, 2026

Adoptive Immunotherapy of iNKT Cells in Glucose-6-Phosphate Isomerase (G6PI)-Induced RA Mice
Published on: January 31, 2020
[Defect of glycosylation of immunoglobulin G in rheumatoid arthritis patients]
Ewa Gińdzieńska-Sieśkiewicz1, Piotr Adrian Klimiuk, Izabela Domysławska
1Klinika Reumatologii i Chorób Wewnetrznych Akademii Medycznej w Białymstoku. ewajsieskiewicz@op.pl
Abstract:
Rheumatoid arthritis (RA) is a multisystem disorder in which immunological abnormalities result in symmetrical joint inflammation, articular erosion, and extra-articular involvement. The etiology of RA is still unknown, but a defect in the glycosylation of IgG may be involved in its immunopathogenesis. Several studies have shown a correlation between the amount of IgG lacking galactose and the activity of RA. IgG galactosylation has been shown to be a useful marker of early RA and an indicator of poor prognosis. Analysis of IgG galactosylation may offer an insight into disease pathogenesis and may also be useful in RA diagnosis.
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