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Updated: Aug 10, 2026

Micromanipulation of Circulating Tumor Cells for Downstream Molecular Analysis and Metastatic Potential Assessment
Published on: May 14, 2019
Cancer and thrombosis
1University of Amsterdam and Department of Medicine, Academic Medical Center, 1105 AZ Amsterdam, The Netherlands. m.m.levi@amc.uva.nl
Abstract:
Cancer is frequently complicated by thrombosis, which may even be the first sign of an unrecognized cancer. There are several risk factors for cancer-associated thrombosis, such as type of malignancy, the presence of metastatic disease, and the use of chemotherapy. In most patients with cancer, a procoagulant state can be identified, ranging from subclinical laboratory abnormalities to full-blown disseminated intravascular coagulation. A specific entity is the occurrence of thrombotic microangiopathy that is specifically related to (high-dose) chemotherapy and radiotherapy. The pathogenetic pathways that play a role in the cancer-associated coagulopathy have been identified in recent years.
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