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Updated: Aug 15, 2026
A Model for Perineural Invasion in Head and Neck Squamous Cell Carcinoma
Published on: January 5, 2017
Head and neck melanoma
Matthew A Kienstra1, Tapan A Padhya
1Head and Neck Oncology Division, H. Lee Moffitt Cancer Center & Research Institute, Tampa, FL 33612, USA. kienstma@moffitt.usf.edu
Background:
Melanoma of the head and neck and its treatment are complex issues. The behavior of head and neck melanoma is aggressive, and it has an overall poorer prognosis than that of other skin sites.
Methods:
The authors review current data on the treatment of head and neck melanoma, including both cutaneous and mucosal melanoma.
Results:
Current understanding of the behavior of head and neck melanoma is reviewed and treatment stratagems are presented. Controversies in treatment include lymphoscintigraphy with sentinel node biopsy, nodal dissection, margin size, role of radiation therapy, and reconstruction. The management goal is to treat melanoma aggressively while minimizing the effects of treatment on patient quality of life.
Conclusions:
Due to its aggressiveness, head and neck melanoma should be treated aggressively when morbidity is not significantly increased. Patient specific treatment is imperative.
