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Seizure occurrence in patients with chronic renal insufficiency in regular hemodialysis program

Fulvio Alexandre Scorza1, Marly de Albuquerque, Ricardo Mario Arida

  • 1Laboratório de Neurociências, Núcleo de Pesquisas Tecnológicas, Universidade de Mogi das Cruzes, Mogi das Cruzes, SP, Brasil. scorza.nexp@epm.br

Arquivos De Neuro-Psiquiatria
|November 1, 2005
PubMed

Insights

Seizures during hemodialysis are uncommon in end-stage renal disease patients. While some may experience seizures during dialysis, they typically do not become chronic, suggesting occasional rather than persistent neurological events.

Area of Science:

  • Nephrology
  • Neurology

Background:

  • End-stage renal disease (ESRD) patients undergoing hemodialysis are susceptible to complications.
  • Hemodialysis-associated seizures represent a significant, though infrequent, complication in this population.

Purpose of the Study:

  • To investigate the occurrence and characteristics of seizures in patients with ESRD undergoing dialysis.
  • To determine if seizures in ESRD patients on dialysis tend to become chronic.

Main Methods:

  • Retrospective review of medical histories of 189 patients undergoing dialysis.
  • Selection of five patients with a history of seizures for detailed analysis.
  • Classification of seizure types and timing relative to dialysis sessions.

Main Results:

  • Five ESRD patients experienced seizures during the study period.
  • Seizure types included generalized tonic-clonic, partial with secondary generalization, and unclassified.
  • Three patients had seizures exclusively during dialysis; one experienced convulsive status epilepticus.
  • Two patients had a prior history of seizures before commencing dialysis.

Conclusions:

  • Seizures in patients with renal failure undergoing hemodialysis are generally occasional events.
  • The data suggests that these seizures do not typically develop into a chronic condition.
  • Further research may clarify the specific mechanisms and risk factors for hemodialysis-associated seizures.

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