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Desmosomes in uterine epithelial cells decrease at the time of implantation: an ultrastructural and morphometric

Amanda M Preston1, Laura A Lindsay, Christopher R Murphy

  • 1School of Medical Sciences (Anatomy and Histology), The University of Sydney, NSW 2006, Australia.

Journal of Morphology
|November 1, 2005
PubMed
Summary
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During rat pregnancy, uterine epithelial cell desmosomes significantly decrease, facilitating blastocyst invasion. This reduction in cell adhesion is crucial for successful implantation.

Area of Science:

  • Reproductive Biology
  • Cell Biology
  • Histology

Background:

  • Uterine epithelial cell displacement is essential for blastocyst implantation.
  • Desmosomes, key cell adhesion structures, are implicated in this process.

Purpose of the Study:

  • To investigate changes in the number and structure of desmosomes in rat uterine epithelial cells during the peri-implantation period.

Main Methods:

  • Transmission electron microscopy was used to examine rat uterine epithelial cells.
  • Quantification of desmosomes along the lateral plasma membrane was performed across different days of pregnancy.

Main Results:

  • A significant decrease in the number of desmosomes was observed along the entire lateral plasma membrane as pregnancy progressed.

Related Experiment Videos

  • Desmosome numbers decreased significantly on the apical portion of the lateral plasma membrane throughout the examined days.
  • On day 6 of pregnancy, larger, 'giant desmosomes' were noted, alongside a reduction in uterine epithelial cell height.

    • Conclusions:

    • There is a significant reduction in uterine epithelial cell height and desmosome number during rat implantation.
    • This reduction in desmosomes likely decreases lateral cell adhesion, facilitating blastocyst invasion.