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Updated: Aug 15, 2026

Expanding the Comprehension of the Tumor Microenvironment using Mass Spectrometry Imaging of Formalin-Fixed and Paraffin-Embedded Tissue Samples
Published on: June 29, 2022
Tissue microarrays from HOPE-fixed specimens allow for enhanced high throughput molecular analyses in
Torsten Goldmann1, Daniel Drömann, Marouane Marzouki
1Research Center Borstel, Clinical and Experimental Pathology, Germany. tgoldmann@fz-borstel.de
Abstract:
In this study, we describe a technique that allows for the production and the use of tissue microarrays (TMA) from HOPE-fixed, paraffin-embedded specimens. The combination of these two technologies unites the advantages of the high throughput aspects in TMA, with good preservation of nucleic acids, proteins, and morphology of HOPE-fixed tissues, thus substantially widening the capabilities presently available for molecular studies in paraffin-embedded tissues.
