[Use of superoxide dismutase in infusion therapy of experimental hemorrhagic shock]

The work deals with study of the possibility of increasing the efficacy of infusion therapy in massive blood loss by preliminary administration of superoxide dismutase (SOD). The data obtained bear evidence that in preliminary administration of SOD infusion of a blood substitute produces a more marked and stable improvement of central hemodynamics and microcirculation, oxygen regimen, and acid-base equilibrium in rats. A significant increase of the circulation volume and stroke volume of the heart following SOD injection may be linked with lesser intensity of lipid peroxidation in the cardiocyte membranes during reoxygenation.