Related Experiment Video
Updated: Aug 15, 2026

Single Nucleotide Polymorphism-sensitive FISH Detection of Locus-specific Ribosomal RNA Transcription in Drosophila melanogaster
Published on: March 28, 2025
[Genetic polymorphism analysis of 6 STR loci on the X chromosome in Xi'an Han population]
Bing Yu1, Qun-xia Qin, Jin-cheng Yan
1The National laboratory of the Ministry of Health for Forensic Science, College of Medicine, Xi'an Jiaotong University, Xi'an 710061, China.
Objective:
To investigate the alleles and genotypes frequency of 6 short tandem repeat (STR) loci (DXS8378, DXS7132, DXS6789, DXS101, HPRTB and DXS7423) on the X chromosome in Han population.
Methods:
The six X-chromosome STR loci were analyzed by PCR following polyacylamide gel electrophoresis and silver stain.
Results:
Among 120 females from Xi'an Han population, the number of alleles in the 6 loci (DXS8378, DXS7132, DXS6789, DXS101, HPRTB and DXS7423) were 5, 6, 11, 10, 8, and 4 respectively; the number of genotypes in the 6 loci were 10, 17, 29, 32, 22, and 7 respectively; Exact tests demonstrated genotype frequencies in females had no departure from Hardy-Weinberg equilibrium.
Conclusion:
The six X-chromosome STR loci are appropriate for individual identification, paternity testing involving a female child and for study on related disease.
Related Concept Videos
Single Nucleotide Polymorphisms-SNPs
The Ratio of X Chromosome to Autosomes
Normal male Drosophila has a ratio of one X chromosome to two sets of autosomes. In contrast, normal female Drosophila...
Pedigree Analysis
X and Y Chromosomes
The germline cells such as egg and sperm cells carry only half the number of chromosomes, i.e., 22 autosomes and one sex chromosome. All eggs have an X chromosome, while sperm cells can carry an X or...
The Y Chromosome Determines Maleness
Evolution
Around 300 million years ago, the two sex chromosomes diverged from two identical autosomal chromosomes. Over time, the Y chromosome has lost most of its genes, shrinking in size. Today,...
Genome-wide Association Studies-GWAS
GWAS does not require the identification of the target gene involved in...

