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Updated: Aug 7, 2026

Functional Assessment of Intestinal Motility and Gut Wall Inflammation in Rodents: Analyses in a Standardized Model of Intestinal Manipulation
09:44

Functional Assessment of Intestinal Motility and Gut Wall Inflammation in Rodents: Analyses in a Standardized Model of Intestinal Manipulation

Published on: September 11, 2012

[Clinical-functional and morphological changes in the large intestine in patients with chronic abdominal ischemia]

I A Shashkova, L A Zvenigorodskaia, S G Khomeriki

    Eksperimental'Naia I Klinicheskaia Gastroenterologiia = Experimental & Clinical Gastroenterology
    |November 2, 2005
    PubMed

    Insights

    This study investigates clinical variants of ischemic lesions of the large intestine (ILLI) in chronic abdominal ischemia (CAI) patients. Findings show ILLI severity ranges from reversible functional issues to severe organic damage, with distinct clinical and morphological features.

    Area of Science:

    • Gastroenterology
    • Vascular Surgery
    • Pathology

    Context:

    • Chronic abdominal ischemia (CAI) affects visceral blood flow.
    • Cardiovascular pathology frequently underlies CAI.
    • Ischemic lesions of the large intestine (ILLI) are a significant complication.

    Purpose:

    • To study clinical variants of ischemic lesions of the large intestine (ILLI).
    • To analyze patients with chronic abdominal ischemia (CAI) and cardiovascular pathology.
    • To differentiate ILLI from other large intestine diseases.

    Summary:

    • Examined 42 patients with suspected ILLI and cardiovascular issues causing hemodynamic disorders.
    • Utilized comprehensive diagnostics including clinical, laboratory, and morphological assessments.
    • Identified a spectrum of ILLI outcomes, from functional disturbances to severe organic damage, each with unique characteristics.

    Impact:

    • Highlights the diverse clinical presentations and pathological changes in ILLI.
    • Emphasizes the importance of detailed diagnostics for accurate ILLI diagnosis.
    • Provides insights into the relationship between ischemia severity and large intestine damage.

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