Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Tissue-engineered hybrid tooth and bone.

Conan S Young1, Harutsugi Abukawa, Rose Asrican

  • 1Department of Cytokine Biology, Forsyth Institute, Boston, Massachusetts 02115, USA.

Tissue Engineering
|November 2, 2005
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Digitally Guided Frontal Sinus Fracture Fixation: A Point-of-Care "In-House" Biomodel Protocol with Cyanoacrylate-Assisted Fragment Stabilization.

Journal of clinical medicine·2026
Same author

Donor-site morbidity and aesthetic outcomes in patients undergoing head and neck reconstruction with anterolateral thigh or latissimus dorsi flaps: A systematic review and meta-analysis.

Journal of cranio-maxillo-facial surgery : official publication of the European Association for Cranio-Maxillo-Facial Surgery·2025
Same author

Value of Personal Engagement Versus Delegation in Surgical Practice.

Journal of oral and maxillofacial surgery : official journal of the American Association of Oral and Maxillofacial Surgeons·2025
Same author

Extraenteric Malignant Gastrointestinal Neuroectodermal Tumor of the Neck: A Diagnostic Challenge.

International journal of molecular sciences·2025
Same author

Interventional treatment strategies for arteriovenous malformations of the mandible and maxilla: 30-year institutional case series.

Interventional neuroradiology : journal of peritherapeutic neuroradiology, surgical procedures and related neurosciences·2025
Same author

RE: TMJ Concepts Patient-Fitted Temporomandibular Joint Reconstruction Prosthesis System: Results From a Food and Drug Administration Postmarket Surveillance Prospective Cohort Study.

Journal of oral and maxillofacial surgery : official journal of the American Association of Oral and Maxillofacial Surgeons·2025
Same journal

Change in u.s. Patent infringement law.

Tissue engineering·2009
Same journal

Functional reconstruction of the jaw bones using poly(l-lactide) mesh and autogenic particulate cancellous bone and marrow.

Tissue engineering·2009
Same journal

Effect of the structure of bone morphogenetic protein carriers on ectopic bone regeneration.

Tissue engineering·2009
Same journal

Cross-linking of gelatin with carbodiimides.

Tissue engineering·2009
Same journal

Early treatment of diabetes with porcine islets in a bioartificial pancreas.

Tissue engineering·2009
Same journal

Permeability of filters used for immunoisolation.

Tissue engineering·2009
See all related articles

This study bioengineered hybrid tooth-bone tissues to treat tooth loss and bone resorption. The novel approach successfully created integrated tooth and bone structures, showing promise for future clinical applications.

Area of Science:

  • Regenerative Medicine
  • Biomaterials Science
  • Dental Research

Background:

  • Tooth loss and alveolar bone resorption are significant clinical challenges.
  • Current treatments for severe tooth loss and bone defects have limitations.
  • Tissue engineering offers a potential solution for restoring tooth and bone structures.

Purpose of the Study:

  • To investigate the utility of a hybrid tissue-engineering approach for creating tooth-bone constructs.
  • To evaluate the integration and histological characteristics of bioengineered tooth and bone tissues.
  • To assess the potential for clinical application in treating tooth loss with alveolar bone resorption.

Main Methods:

  • Bioengineered tooth implants using pig third molar tooth bud cells on polyglycolide (PGA) and polyglycolide-colactide (PLGA) scaffolds.

Related Experiment Videos

  • Generated bone implants from pig bone marrow progenitor cells on PLGA scaffolds.
  • Sutured and reimplanted hybrid tooth-bone constructs in rat omenta for 8 weeks.

    • Main Results:

    • Histological analysis confirmed the presence of dentin and enamel in the tooth portion.
    • Immunohistochemistry showed osteocalcin and bone sialoprotein-positive bone in the bone portion.
    • Collagen type III-positive connective tissue at the interface resembled periodontal ligament and tooth root structures.

    Conclusions:

    • A hybrid tooth-bone tissue-engineering strategy successfully created integrated tooth and bone tissues.
    • The bioengineered constructs exhibited key histological features of natural tooth and bone.
    • This approach demonstrates potential for clinical treatment of tooth loss with alveolar bone resorption.