Jove
Visualize
Contact Us

Related Experiment Videos

Pyrolytic carbon-coated Dacron grafts.

W V Sharp1, P C Teague

  • 1Vascular Research Laboratory, Akron City Hospital, Ohio.

Surgical Forum
|January 1, 1978
PubMed
Summary

A novel pyrolytic carbon surface, ULTI, significantly improved vascular graft patency in dogs, achieving 97.5% success. This advanced biomaterial shows great promise for small vessel replacement, maintaining substrate integrity.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Phenyl-pyridylhydantoins.

Journal of the American Chemical Society·2010
Same author

PANTOTHENIC ACID AND THE UTILIZATION OF GLUCOSE BY LIVING AND CELL-FREE SYSTEMS.

The Journal of general physiology·2009
Same author

Evaluation of expanded polytetrafluoroethylene arteriovenous access grafts onto which microvessel-derived cells were transplanted to "improve" graft performance: preliminary results.

Annals of vascular surgery·1998
Same author

Effect of HLA matching on organ distribution among whites and African-Americans.

Transplantation·1994
Same author

Pharmacologic modulation of intimal hyperplasia in canine vein interposition grafts.

Journal of vascular surgery·1993
Same author

Initial experience with laparoscopic surgery: establishing a new surgical procedure.

Journal of laparoendoscopic surgery·1992
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Area of Science:

  • Biomaterials Science
  • Vascular Surgery
  • Surface Engineering

Background:

  • Vascular grafts are crucial for replacing damaged or diseased vessels.
  • Small-diameter vascular prostheses often suffer from poor patency rates.
  • Pyrolytic carbon is a known biocompatible material with potential for vascular applications.

Purpose of the Study:

  • To evaluate the efficacy of a new pyrolytic carbon surface (ULTI) on a dacron substrate as a vascular biomaterial.
  • To assess the patency rates of ULTI-coated dacron grafts in a canine model.
  • To determine if the ULTI coating process affects the physical properties of the dacron substrate.

Main Methods:

  • A novel pyrolytic carbon surface (ULTI) was deposited onto a loosely knitted dacron substrate.
  • The modified dacron grafts were implanted in a canine model.
  • Graft patency was assessed and compared to control grafts.
  • Physical properties of the dacron substrate were analyzed before and after ULTI coating.

Main Results:

  • The ULTI-coated pyrolytic carbon dacron grafts achieved a patency rate of 97.5%.
  • Control grafts exhibited a significantly lower patency rate of 33%.
  • The physical properties of the dacron substrate remained unaltered after the ULTI carbon deposition process.

Conclusions:

  • The ULTI-modified pyrolytic carbon on a dacron substrate demonstrates excellent performance in a canine model.
  • This biomaterial represents a highly promising advancement for small vessel replacement surgery.
  • The durability and biocompatibility of the ULTI surface warrant further investigation for clinical translation.

Related Experiment Videos