Signalling via cGMP: lessons from Drosophila

Guanosine 3', 5'-cyclic monophosphate (cGMP) signalling has received increasing attention over the last decade, since the discovery of the gaseous signalling molecule, nitric oxide, which activates cGMP synthesis. Furthermore, research into cGMP signalling has also been stimulated by the development of Viagra and pharmacologically active related compounds, which act to prevent cGMP breakdown. While much is known about the biochemical aspects of components of the cGMP signalling pathway, the precise in vivo roles of such components have only recently come to light through work in model organisms. This review outlines recent work utilising the genetic model organism Drosophila melanogaster in studies of organotypic cGMP signalling. While organisms such as Drosophila may not be the obvious choice for such studies, use of this model has proved that unique and detailed insights for cGMP signalling can be achieved.