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Updated: Aug 15, 2026

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Kinase Inhibitor Screening In Self-assembled Human Protein Microarrays
Published on: October 23, 2019
The identification of potent and selective imidazole-based inhibitors of B-Raf kinase
Andrew K Takle1, Murray J B Brown, Susannah Davies
1Department of Medicinal Chemistry, Neurology and GI Centre of Excellence for Drug Discovery, GlaxoSmithKline Pharmaceuticals, New Frontiers Science Park, Third Avenue, Harlow, Essex CM19 5AW, UK. Andy.K.Takle@gsk.com
Bioorganic & Medicinal Chemistry Letters
|November 2, 2005
Abstract:
A novel triarylimidazole derivative, SB-590885 (33), bearing a 2,3-dihydro-1H-inden-1-one oxime substituent has been identified as a potent and extremely selective inhibitor of B-Raf kinase.

