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Chickenpox complications in Saudi Arabia: Is it time for routine varicella vaccination?
Maha Almuneef1, Ziad A Memish, Hanan H Balkhy
1Department of Infection Prevention and Control, King Abdulaziz Medical City-King Fahad National Guard Hospital, PO Box 22490, Riyadh 11426, Saudi Arabia.
Insights
Chickenpox (varicella) complications are rare but can be severe, especially in adults. This study highlights the need for varicella vaccination in Saudi Arabia to reduce disease burden.
Area of Science:
- Infectious Diseases
- Pediatrics
- Public Health
Background:
- Chickenpox (varicella) is a common childhood illness, but severe cases and hospitalizations can occur.
- The full spectrum of varicella complications is often underestimated in pediatric populations.
Purpose of the Study:
- To determine the complication rate of chickenpox in the Saudi National Guard population.
- To establish a baseline for varicella-related morbidity and mortality in Saudi Arabia.
Main Methods:
- Prospective follow-up of 3802 reported chickenpox cases at King Abdulaziz Medical City, Riyadh.
- Data collected from June 2001 to December 2003, focusing on complication development.
Main Results:
- 1.5% of chickenpox cases developed complications, with skin infections and pneumonia being most common.
- Adults had higher rates of pneumonia and hospitalization compared to children.
- The overall fatality rate was 0.05%, with two deaths reported.
Conclusions:
- Chickenpox complications, though infrequent, necessitate monitoring and can impact adult populations disproportionately.
- Findings support the integration of the varicella vaccine into routine childhood immunization programs in Saudi Arabia.
Introduction:
Varicella zoster (chickenpox) infection is a common and benign disease of childhood. The predominance of uncomplicated cases in children tends to overshadow the morbidity associated with severe cases and the resultant hospitalization.
Objective:
The objective was to establish the complication rate of chickenpox in the Saudi National Guard population over a 2(1/2)-year period.
Methods:
All reported cases of chickenpox at the King Abdulaziz Medical City, Riyadh were prospectively followed for development of complications during the period between 1 June 2001 and 30 December 2003.
Results:
A total of 3802 cases of chickenpox were reported and followed during the acute illness phase. The majority of cases, 2984 (78%), occurred in children less than 15 years of age. Among all chickenpox cases, 78 (2%) required hospitalization, and 50 patients developed 58 (1.5%) complications. Skin and soft tissue infections were the most common complications, 20 (34%), followed by pneumonia in 16 (28%), bacteremia in six (10%), encephalitis in four (7%) and necrotizing fasciitis in four (7%). Complications were less common in children (36/2984, 1.2%) as compared to adults (14/818, 1.7%) (p = 0.26). However, pneumonia (p = 0.03) and hospitalization (p = 0.004) were more common in adults as compared to children. The overall fatality rate was 0.05%; two patients died, one aged two months the other 28 years.
Conclusion:
These data provide a baseline for morbidity and mortality from chickenpox, and further support the inclusion of varicella vaccine in the routine childhood immunization program in Saudi Arabia.
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