Related Experiment Video
Updated: Aug 15, 2026

Micro-Colony Forming Unit Assay for Efficacy Evaluation of Vaccines Against Tuberculosis
Published on: July 28, 2023
Safety issues regarding new vaccines for tuberculosis, with an emphasis on post-exposure vaccination
1Department of Microbiology, Immunology and Pathology, Colorado State University, Fort Collins, CO 80523, USA. Ian.Orme@ColoState.EDU
Abstract:
There are several new types of vaccines that have become potential candidates for the prevention of tuberculosis. While these have been tested in the conventional animal models, less emphasis has been placed as yet on the development of safety testing procedures. This is particularly important if we are ever going to use such vaccines in a therapeutic or post-exposure mode, in which the risk of severe "Koch-like" reactions may be high. A further element that badly needs more research is the state of immunity already preexisting in the infected host and how vaccine induced immunity may interact with this.
Related Concept Videos
Pulmonary Tuberculosis V
Latent tuberculosis infection occurs when TB bacteria are present in a person's body, but are not causing illness or symptoms. It is not contagious, and preventive treatment is crucial to avoid the progression...
Pulmonary Tuberculosis I
Causative Organism
The primary infectious agent causing tuberculosis is Mycobacterium tuberculosis, a slow-growing, acid-fast, aerobic rod that exhibits sensitivity to heat and ultraviolet light. Instances of Mycobacterium bovis and Mycobacterium avium contributing to the development of TB infection are rare.
Mode of...
Pulmonary Tuberculosis IV
Several diagnostic approaches are used to detect TB. The conventional method is the Tuberculin Skin Test (TST), also known as the Mantoux test. However, this method has...
Pulmonary Tuberculosis III
The first classification is based on the development of the disease, and it includes the following categories:
Smallpox
Pulmonary Tuberculosis II
Here is a detailed explanation of its pathophysiology:
Transmission: The process begins when a person inhales droplet nuclei containing M. tuberculosis. These are typically released into the air when an individual with pulmonary or...

