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Corticosteroids peroperatively diminishes damage to the C-fibers in microscopic lumbar disc surgery
Anders Lundin1, Anders Magnuson, Kjell Axelsson
1Department of Orthopaedic Surgery, Orebro University Hospital, Orebro, Sweden. anders.lundin@orebroll.se
Study Design:
A subgroup analysis of patient outcomes from a double-blind randomized controlled study comparing corticosteroid versus saline in microscopic lumbar disc surgery.
Objectives:
To study if the use of corticosteroids combined with surgery alleviates the damage to the nerve fibers in lumbar disc herniation.
Summary Of Background Data:
The use of quantitative sensory testing can detect damage to the myelinated A-delta fibers (cold sense) and the unmyelinated C-fibers (warmth sense). Corticosteroids combined with surgery in lumbar disc surgery enhance the outcome after surgery in terms of less pain and more rapid rehabilitation.
Methods:
Analyzing quantitative sensory testing before surgery and after 2 weeks and 2 years.
Results:
In the corticosteroid group, we saw a statistically significant normalization for the warmth disturbance comparing with control group, which not was detected concerning the cold disturbance.
Conclusions:
The use of corticosteroids combined with surgery seems to protect some of the damage to the C-fibers in lumbar disc herniation.
