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Mean platelet volume in the patients with cardiac syndrome X

Serkan Cay1, Funda Biyikoglu, Gokhan Cihan

  • 1Department of Cardiology, Yuksek Ihtisas Heart-Education and Research Hospital, Ankara, Turkey. cayserkan@yahoo.com

Journal of Thrombosis and Thrombolysis
|November 2, 2005
PubMed

Insights

Patients with cardiac syndrome X have a higher mean platelet volume, indicating increased platelet activity. This finding suggests potential lifestyle modifications may improve symptoms in individuals with this condition.

Area of Science:

  • Cardiology
  • Hematology

Background:

  • Cardiac syndrome X (angina with normal coronary arteries) is a diagnosis of exclusion with unclear mechanisms.
  • While prognosis is generally good, symptoms significantly impact quality of life.
  • Mean platelet volume (MPV) reflects platelet size and function; larger platelets are more active.

Purpose of the Study:

  • To evaluate and compare the mean platelet volume (MPV) in patients with cardiac syndrome X and stable angina.
  • To investigate the relationship between MPV and cardiac syndrome X.

Main Methods:

  • A study was conducted involving 80 patients with cardiac syndrome X (Group A) and 67 patients with stable angina (Group B).
  • Mean platelet volume was measured and compared between the two groups.

Main Results:

  • Patients with cardiac syndrome X (Group A) had a significantly higher mean platelet volume (10.55 +/- 1.08 fl) compared to patients with stable angina (Group B) (9.39 +/- 0.58 fl).
  • The difference in MPV between the groups was statistically significant (P < 0.001).

Conclusions:

  • Elevated platelet size, as indicated by higher MPV, is associated with adverse cardiac events.
  • MPV was found to be increased in cardiac syndrome X, similar to acute coronary syndromes.
  • Lifestyle modifications may help optimize platelet size and alleviate symptoms in cardiac syndrome X patients.
Abstract

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