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Published on: April 22, 2019
Bcl-2 as prognostic factor in head and neck squamous cell carcinoma
Lorenzo Lo Muzio1, Silvia Falaschini, Antonio Farina
1Department of Surgical Sciences, University of Foggia, Foggia, Italy. lomuziol@tin.it
Oncology Research
|November 3, 2005
Summary
Bcl-2 expression in oral squamous cell carcinoma (OSCC) may predict patient survival. Lack of Bcl-2 expression indicates aggressive OSCC, suggesting its potential as an early prognostic marker.
Area of Science:
- Oncology
- Molecular Biology
- Pathology
Background:
- Oral squamous cell carcinoma (OSCC) is a significant global health concern.
- Accurate prognostic markers are crucial for effective OSCC management.
- The role of bcl-2 expression in predicting OSCC outcomes requires further investigation.
Purpose of the Study:
- To investigate the predictive value of bcl-2 expression for clinical outcomes in patients with OSCC.
- To determine the association between bcl-2 expression and clinicopathological variables.
- To evaluate bcl-2 as a potential early prognostic marker in OSCC.
Main Methods:
- Retrospective analysis of 66 OSCC cases using immunohistochemistry for bcl-2 expression.
- Statistical analysis of bcl-2 expression with age, gender, histological grading, TNM staging, recurrence, and survival rates.
- Univariate and multivariate Cox regression analyses were performed.
Main Results:
- Bcl-2 expression was observed in 54.5% of OSCC cases; 44.5% were negative.
- No significant association was found between bcl-2 expression and baseline clinicopathological variables.
- Bcl-2-positive patients showed significantly improved overall survival (p = 0.048) compared to bcl-2-negative patients.
Conclusions:
- Bcl-2 expression is independently associated with improved overall survival in OSCC.
- Lack of bcl-2 expression may signify aggressive biological behavior in OSCC.
- Bcl-2 could serve as an early prognostic marker for oral squamous cell carcinoma.
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